Would a monster of the week format be better?
Think X-files meets Buffy meets Scooby Doo.
Every week new monster or mystery the gang are thrown into.
The government science building nearby could be the catalyst for many of the stories, or Dustin messing around with science projects, accidentally makes a time machine, doesn't know how he did it, time travel episode.
a Vampire family move into town, a small zombie outbreak, ghosts, aliens, werewolves, invasion of the body snatchers, killer robots etc etc