Your intentions are great, this movie is overlooked as a gem of 60's Sci-Fi. But I don't see a remake as being necessary. Granted remakes are hardly ever necessary unless the director is taking us in a completely different direction. One example of that would Scorsese's remake of "Cape Fear". According to an interview he did at the time he said he like the first version of "Cape Fear" but he felt the family in the movie was far too innocent and goodie-goodie, he wanted there to be conflict within the family. While I didn't enjoy his vision, I appreciated his effort and saw that he wasn't just retelling the story with a current group of actors, he was really telling the story with a whole new dramatic twist. So a remake was justified for him.
Being a big fan of "Fantastic Voyage" I don't know what else could be done to make it really better. Of course CGI would be employed to improve the effects, but frankly I think the visuals in this movie are very beautiful and making them more realistic wouldn't make them better. Even the effects for "Inner Space" were probably more realistic of human body internals than this movie, but they weren't beautiful to look at.
As for the plot, I'm sure some juggling of the roles to make the bad guy into a bad girl, or make the hero a black guy or make the good doctor blind or some other gimmick could be dreamed up but again it wouldn't make it better.
And doing a remake of any movie just to plug in current actors is a waste of time to me. So I guess for there to be a remake of "Fantastic Voyage" that I would want to see it would have to be done by a director who really had a vision going off in a completely different direction. I don't know what that is but then I'm not the creative sort, so who knows.
As for the science in this movie, of course there's the issue of the mass not being reduced and thus the sub would still weigh tons and crush the floor tiles. But I read one solution to this would be for the entire lab to be in outer space and thus with no gravity to worry about you just have to keep the velocities down to avoid any problems with mass. I agree this is pretty farfetched but it's better than Asimov's idea about reducing Planck's Constant. "Hey Isaac, that's why the call it a CONSTANT, it can't be changed, man."
tmw
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