Some guesses and theories...
To be clear I have no inside knowledge at all. This is all guessing.
1: it seems like Tony being rescued by Captain Marvel from being trapped in space seems to be the quickest and easiest theory... But I'm not a fan of that one. I think Tony is going to be introduced to a much more powerful being, The Watcher, Eternity, maybe even The Living Tribune. There has been talk that one of these might make an appearance, and this seems like a more subtle touch then just having them appear and begin fighting Thanos.
2: Building off of the 1st, Tony is introduced to a new power, and builds a new armor using the new power source. I'm not sure they will give it the exact name, but I'm thinking power Cosmic gets an introduction here. Its not new to the comics for Tony to build armor off of magic/alien powers, but it would be a departure for the movie version.
3: One or more of the heroes that are tied to the stones, somehow still exist within the stone, and can manipulate it to some degree. Gamora is the odds on favorite, since we know she is hidden away in the soul stone. But would it be so hard to believe that Vision could find a way to upload his intelligence into the mind stone? Or that Strange could find a way to manipulate the time stone?
4: The Incredible Hulk will wield an infinity stone. Of the beings that might be able to do this, it comes down to Hulk and Thor. Thor already had his "I'm a badass" moment when he survived the power of a star. Its time for Hulk to get his screen time. I was originally thinking how awesome it would be to have Hulk pull the power stone away from Thanos. Maybe it would make him so powerful that he can shrug off the effects of the other stones. But then I thought about him getting the Mind stone... and we have an incredibly smart hulk... that might be something to see.
5. We will get a flash back of Hawkeye, pacing in front of the tv, as reports of the Avenger's fighting the alien hordes can be heard in the background. His wife tells him to go, save the world. He insists that Cap and the others can handle it without him. And then the "snap" and Clint's entire family goes up in dust. The only problem with this theory is that the fight happens in Wakanda, so I'm not sure if the rest of the world is even aware its going on...
6. This is probably the biggest jump of all of them. Mephisto appears to offer Clint the power to avenge his family. Mephisto, was part of the original Infinity Gauntlet story, and it would be cool to see him introduced, even as a bit role to be used later in another movie.
What do you guys think? Any theories you guys want to throw out?