Surely it will just be John Krasinski and Emily Blunt?

its pretty obvious it'll be him after being Reed Richards in Dr Strange 2, Patrick Stewart played a variant to his original XMen character so surely the same applies to JK as RR..

Now if its to be JK then Sue Storm will obviously be his wife , who had to turn down Black Widow in Iron Man 2 bc she was doing a silly jack black comedy which must secretly seriously piss her off, so finally getting cast in another major MCU role will go someway to make up for losing the role that turned ScarJo into a worldwide megastar with net worth of about two hundred million dollars.

Thing will be whoever just some wrestler ,and Johnny Storm will probably be some fairly unknown young guy (maybe a blonde guy like in the comics)