I really don't have much. I'd kind of like to see Howard have a reunion with his father, but only if it were on his own terms.
shareThe group develops a new particle theory for the Hadron Collider. It is tested, and creates a mini black hole that destroys the Earth. Very definitive ending.
shareSheldon hits his head and becomes a normal person. Still as smart but without all his quirks.
shareAlso for the elevator to get fixed, Sheldon to get a Nobel, and Penny's maiden name be revealed. And for Amy to get pregnant, since the Season 2 finale of Young Sheldon states that Sheldon does have children someday. It said nothing about Amy, but who else would it be. Maybe if Sheldon wins a big award or something, that'll put him in the mood for coitus that's not on Amy's birthday.
shareSheldon realizing Amy is a mutt and coming out of the closet.
Leonard discovering something amazing or getting a huge promotion/job.
Raj to just go away.
Howard to go back to being a desperate funny sleaze.
Bernadette to go with Raj.
Penny, to start feeling insecure after Leonard's promotion and starts treating him better.