Least favorite characters

Amelia. She is a nasty bitch. I loved the old episodes, but season 12 there are no good leading men. That "sister" thing is the pits.

Edwards & Derek

I 100% agree with the OP on April Kepner and Amelia Shepherd. I fast-forwared through the vast majority of their scenes. I don't care about them at all. The worst episode I have seen is the one where Amelia gives a lecture on Dr. Herman's brain tumor. Horrid. April and Amelia, to me, are cut from the same cloth. Both pinch-faced whiners, always ready to get hysterical at the least thing. Ugh. Seems like every episode either one or both of them are ugly crying, screaming, having a temper tantrum or can't seem to shut the h up. I have no idea what any man would ever see in either one of them. April is pretty, but not worth her constant over-analyzing every aspect of her life and whining. Amelia has no redeeming qualities whatsoever, and it kind of depresses me that it looks like she and Owen are going to be a big story line and be on the show for ages and ages.

April....truly wish she had been on the plane and died, instead of Lexie
Jackson....truly wish he had been on the plane and died, instead of Mark
Shane....truly wish he had died, instead of Heather

Amelia Shepherd - Useless and what is up with her hair? Looks like a bad wig.

Izzy Stevens - Annoying, unrealistic, falling too hard and too fast for too many people.

George O'Malley - What a whiner! Awkward and clueless.

Alex Karev - At first I liked his"bad boy" attitude but later he turned ino a sour mess.

Arizona Robbins - What is her appeal?

Karev. Totally overrated, obnoxious, lame, pathetic & boring to death.