In retrospect, was Paul Rudd the only person from this movie to truly have a great career?

Well, Donald Faison did reasonably well for himself with Scrubs as did Jeremy Sisto and Breckin Meyer even if they aren't necessarily A-list. But as for the girls in the movie, we all know what happened to Alicia Silverstone. She did Batman & Robin and just before that, she was being viciously hounded by the press for putting on too much weight.

https://lebeauleblog.com/2011/06/23/what-the-hell-happened-to-alicia-silverstone/

With Brittany Murphy, it seems like her career went off when she bleached her hair and lost a ton of weight to try and fit into the romantic comedy leading lady mold. She probably would have been better suited to quirky supporting character parts, or wacky leads in aburdist comedies. And her last film credits weren’t that great with many b movies and TV ones.

Stacey Dash actually had the worst career because for some reason she became a right wing nut job and her acting career really died.