He's aged 25 years in 7 years!
In 2010, he still looked like a 30 something. I remember thinking 'he doesn't seem to age at a normal rate.'
Look at this picture:
http://www3.pictures.zimbio.com/gi/People+Choice+Awards+2010+Show+GTnsuNcc9y2l.jpg
Now look at this photo from 2017.
http://static1.purepeople.com/articles/6/24/08/56/@/3365998-johnny-depp-lors-du-festival-de-glastonb-950x0-1.jpg
It seriously looks like 25 years of ageing inbetween. One man a 30 something, the other a 50 something (and an unhealthy 50 something.)
I know with a lot of people their age suddenly catches up on them (Matt Damon comes to mind) but this is bad ageing as well. Poor Johnny, he was once 'the worlds sexiest man.'