Can someone please explain?

Also, why Ramse and Cassie don't have side effects like Cole had in season 1?

I was just thinking about that the other day too and I think it is 'cause Cassie and Ramse haven't time traveled as many times as Cole did in the first season of 12 Monkeys and if they time travel again in Season 3 they will probably start to show it affecting them but I think time traveling will be cut down.

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Why Ramse, Cole and Cassie are the only ones who can travel in time?

Originally Cole was thought to be the only one who could time travel because all of Katarina's previous attempts had failed (some of these failures are seen in 207). Katarina knew that Cole could time travel successfully because he was mentioned in Cassie's recording. It's also possible that Katarina already had the memories of meeting Cole in 2015 (I think it's made clear she does have these memories in the 'Paradox' episode, as she still had the card for Cole's father's garage in 2043).

Why don't just give it to someone else then?

As previously mentioned, this wasn't really an option until Ramse jumped. There were limited quantities of the serum and it was known to enact a physical price on the traveler, to the point they could die after a certain number of jumps. They were also having a lot of problems powering the time machine until they got the Spearhead power core.

like, idk, Whitley?

I believe he even volunteered to go at one point. I'm not sure Kat entirely trusts Whitley and may not feel comfortable sending him back in time. Whitley turned against his own father to join the Splinter team and later betrays Kat by teaming up with Ramse, Cassie and Adler. Loyalty doesn't seem to be his strongest characteristic. There is also the fact that he's head of security at the Splinter facility and in the land of scavs, is definitely needed there.

I think trust would be a major factor in choosing someone else to send back. Kat only trusted Cole because she already knew he was fated to go. She can't send her scientists, as she needs them to keep the time machine running and they are not adequately combat trained to be taking on the 12 Monkeys or Messengers. She needs the security team to keep the facility safe and I don't think she could trust Deacon or the West VII members to keep on mission.

There's also the fact that the time machine is slowly destroying their power core. The cores were designed for a slow draw of power over a long period of time. Using the time machine creates huge spikes in the power draw. They already destroyed their first core in season 1, leading to the slaughter at Spearhead to obtain the second core (which was the only other core built). If they overuse the second core by sending more people through time, they could wear it out before the mission is complete. More use also increases the chance the machine will need to be repaired. Spare parts for the machine are lacking.

And isn't Kat able to travel too?

I think by season 2, anyone that takes the injection can time travel. I don't even think they need the serum to time travel, but it creates a tether between the machine and the time traveler and therefore is required if someone wants to return.

Without getting too spoilery, you will see two other characters use the time machine by the end of the season.

Also, why Ramse and Cassie don't have side effects like Cole had in season 1?

There is a brief mention early in season 2 that the serum was improved. It's never stated, but I think it could be assumed that Cassie spent part of those 8 months in the future helping Kat revise the serum. However, episode 208 shows that multiple time jumps can still have physical consequences.

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