S3 should be on the Mexican Cartels
Skip the dull Cali Cartel (and about 15 years) and move the action to Mexico.
They have a lot more colourful characters like El Chapo and Tony Tormenta.
Or they could go back to 1980s Miami and do a series on the Cocaine Cowboys.
"Damn you Weatherby Savings and loan, I spit at you!"