For the science minded


An article about CRISPR being used on humans. Something to keep our brains working until the next and final season.


http://gizmodo.com/the-crispr-gene-editing-tool-is-finally-being-used-on-h-1789042055

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It might not be too late to sneak this in before the series finale.

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I don't have a particular problem with non-germ line editing within the human body, provided that the patient is past child-bearing age and/or promises not to procreate. In the case of most cancer patients, in whom chemo was the original treatment route, they have been rendered sterile anyway, so there doesn't seem much danger that such gene editing will be passed on to future generations, causing dangerous mutations.

Of greater concern to me was the news a couple of months back that an American couple, using the services of an American doctor in Mexico, where such experiments are not technically illegal, gave birth to a "healthy" child (at least according to the doctor's press release -- no independent confirmation has been done of any of the doctor's claims and there was great skepticism and condemnation within the scientific community following the press release) as the result of the first child born with three different cell lines.

No details were given, but the explanations I saw seemed to indicate that the easiest way to do such a thing would be to use an egg from a fertile donor, remove the nucleus, then remove the chromosomes from the egg of a non-fertile mother, combine them with the sperm of fertile father, and insert all of the genetic material into the egg from the fertile donor.

Needless to say, this is risky in the extreme and undoubtedly resulted in a large number of experiments... not working. The hubris of a doctor who would encourage any woman who wanted her own genetic child enough that she would allow him to to expose her to the dangers of super-ovulation (caused by large doses of hormone injections, and creating a serious risk of heart attack or stroke) is bad enough, but if there were any genetic abnormalities that caused her infertility, then the risks that she would pass them on to her child go up, as do the risks that her "chimera" of a child (because that's what the child will be, as he or she will carry the mitochondrial DNA of the egg donor and the "germ-line" DNA of the presumed parents) are intolerable, given my own moral belief structures.

Similar experiments have been done on mice and rats for years now, but never on "higher" animals such as even sheep, so the consequences to any human being are specifically unknown and are banned almost everywhere in the "civilized world."

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