Saw it today. Not sure what the critics are smoking but this movie was a 5/10 at best. Good acting, but very boring with little story and not that funny. It seemed like Jesse just wanted to make a movie about his Jewish heritage without any real idea for a story.
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The film is a psychological drama about complicated family relationships, various personality disorders, mental illness, etc. The title "a real pain" takes on many different meanings throughout the experience.
I actually was not aware until credits started rolling that Jesse Eisenberg wrote and directed the movie himself. What an incredible talent.