Just finished the game: my pro's and con's (ending spoilers)

Pros:
Great story
Great dialogue
Great voice acting
Great animation and technology
Great scenery
LOVED the versatility of the game (combo of detective work, shootouts, hand-to-hand, and car chasing)
Time-saving (not having to drive back to the scene after chases, able to skip drives to scenes)

Cons:
A little repetitive at times
Sometimes the facial difference is so slight between Truth/Doubt/Lie during questioning
Ending was kind of a downer (since I liked the Cole character, I would've liked to have seen him live and have him return for a sequel to continue his redemption process from the war)
Continuity - by that, I mean I got busy and had to put the game down for a stretch, and by the time I got back to playing it, it took a while to get back into the zone of the game with storylines, evidence, remembering who said what, etc. Not very conducive to breaks in playing. This happened to me especially during the thick of the Elysian Fields/Suburban Redevelopment Fund storyline.