New characters
Pheobe Waller-Bridge - Helena, Indy's goddaughter
Mads Mikkelson - Jurgen Voller, An ex-Nazi working with the US government and NASA and the main villain
Boyd Holbrook - Klaber, Voller's henchman and possibly government agent until his control
Shaunette Renee Wilson - Mason, government agent
Toby Jones as Basil, one of Indy's allies in flashback, possibly Helena's father
Antonio Banderas - Ally to Indy
Thomas Kretschmann - assume he's part of the WWII flashbacks
Oliver Richters - Hawk, one of Voller's henchmen
Additionally Anthony Ingruber is apparently in the movie