The film is a metaphor for dying.
The setting only serves to put more obstacles on the "journey",that the crew must overcome.It's not trying to be a sci-fi movie,but a movie about humanities struggle to stave-off death at all cost.And the sacrifices made in the face of that struggle.It's a very good movie in that regard,but if you wanted to pick out all the science flaws you could point out quite a bit.
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