So many good points in this...
I think that George liked Callie, but was afraid to lose her. I didn't like them together. It just seems really strange and the were times when Callie looked like she was a deer trapped in headlights. It went from her going after him, pressing him to a certain extent, to sleeping together, to BOOM! Married. George didn't really get to really make his feelings for her known and understood. He was dealing with the death of his Dad and all of the feelings that go along with it, especially since he was a doctor and a surgeon and he wasn't able to save him... Callie maybe went after him because he was safe. He was cute and funny. She probably in denial or wasn't aware of her sexuality.
Izzie... who knows why the writers did that. Izzie...how do you even explain Izzie? They had even less chemistry than George and Callie. Izzie was supposed to be his "best friend", yet she was never nice to Callie, never supported the reaction ship that Callie and George had, and never supported their marriage. She flirted with him while he was married, said, "I love you" while he was married, downplayed and even kind of dismissed what happened between them... What kind of friend, "best" or otherwise, does that?
Like someone said, he was taken and she needed someone, so she went after him... and then.. well, they both realized that it was wrong and that it shouldn't have happened (they both had looks of horror and wondered what they were doing).. and yes, it was strange that they went right back to being friends. Izzie went from the hockey guy to Alex to Denny to Alex to George then back to Alex... Izzie had her moments, but... I mean she was funny, cute, bubbly, could really make herself relatable to her patients, could bake, could make a home homey... but.... look what she did to Denny. She almost killed him because she was afraid of being alone. She fell in love with a patient. She dragged her friends into the dram, putting all of their educations and carers at risk (not to mention Dr. Bailey's, Dr. Webber's and the hospital's standings. She had that party where she invited half the hospital without letting Meredith know, she gets sick and didn't want anyone to know until Cristina told her tonight and rallied everyone around her. Meredith pushed up and then gave Izzie her wedding! George dies and she laughs (granted she did say that she laughed at funerals) at her funeral and kind of made it all about her. She leaves Alex by note without saying good bye to anyone after all they did for her, she comes back expecting to be welcomed back with open arms, and then leaves again, and this time with all of her bills for Alex to pay. I have a feeling that had George lived, her coming back and then leaving again expecting for Alex to pay all of her bills, would have been the straw that broke the camel's back and he would have just gone off on her and ended the friendship, bringing up everything that she did to everyone.
George I miss. I think that he would have been a fantastic trauma surgeon and ER doctor, that he'd be a great Uncle to Tuck, Zola, Sophia, Baby Bailey, and Ellis... He'd be there for Dr. Bailey when she was having her issues that turned into OCD... He would have been there for Cristina when she was struggling with PTSD from the shooting and the plane crash, when Owen cheated on her, when she was getting ready to leave. He would have been there for Alex when he got shot and when he was dealing with all of the issues of not being on the plane that killed Lexie and Mark and seriously injured Arizona. He would have been there for Callie when she was in her accident and when she was recovering. I c an't picture Izzie in any of those situations or being supportive. Who would he be now, it's hard to say. He just needed time to really grow up, like Alex was able to... I mean, who knew that Alex would be the surgeon, the doctor, and especially the man that he is now... George needed that, too.
He would have been there for Meredith when Derek was shot, when she almost died while having Baby Bailey, when Maggie showed up, when Derek died, and when she was attacked. He wasn't perfect and he knew it. He made mistakes personally and professionally and knew that, too, but he always tried to make things right... He didn't really have the chance to really become the doctor, the surgeon, and most importantly, the man that he was supposed to become. He had some more growing up to do... He was just finding his place in the world, his footing especially after his father died and Burke (who despite his flaws, saw something in George, was an advocate and a supporter for him), especially when Owen saw his natural ability to have his specialty be trauma... I wonder what could have been. I do not condone his cheating, but I think that in someways he was manipulated by Izzie who saw his venerability and used that to her advantage... and that saying of, "Just because you did a horrible thing, doesn't mean you're a horrible person" comes to mind and there are people who use that against him, but yet say Izzie and Alex forever, when he was part of that cheating and Alex cheated on Izzie.... and you have to think the same of ALL the other people who cheated and had affairs as well...
Izzie, on the other hand, just kind of blew things off and didn't always take responsibility for what she did and who she hurt: Alex, Callie, Meredith, Cristina, George... that being said... she needed more time to grow up, too... and I wonder what she is, where she is... if maybe she'll come back in some capacity.... if the she's all right, if she's maybe a OBGYN or a surgeon or a Medical Social Worker or a Patient Advocate (which I think that she might be better at) or if she just has a little shop somewhere for her baked goods and her knitted items. Hmmm..
I really don't know why the writers did that to both George (who did so much to help people, always tried to do the right thing, tried to be so mortal) and to a certain extent Izzie. They didn't give George a great story line (maybe he should have been the one to have gotten cancer or had him hit by the bus at the end of season 4 or the beginning of season 5 to watch him recover!) and hardly gave him any screen time in the first nine episodes of his last season.
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