I don't care for Izzy or Jo for that matter. Izzy did help humanize Alex, but where he truly starting to thrive was in season 8 and Meredith and AZ and even Christina to an extent was responsible for that. Izzy, like Jo & Ava, his mom and even his dad were people he felt he had to take care of-it was his responsibility. He was there for Meredith when she needed him, but then she told him to leave, she would be fine and to go back to Jo. Alex is a fixer.
He was only truly there and attentive to Izzy during her Cancer. Then she got better, refused his help and concern and just left him. He tried to make sure she was getting treatment elsewhere, but she didn't bother to let him know she was ok. She comes back expecting everything to be rosy and even getting a job at another hospital, but he wanted her there and she refused and left him again. Then filed for divorce. She wouldn't communicate with him and much like now, Jo isn't either
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