I totally agree. It has some great comedic moments but is ultimately a tragedy.
I think creating a fictional drug like Substance D was perfect because it allows the viewer to connect with their own personal experiences of whatever drugs they've done in the past. They did a good job at making D feel like it could be any drug out there.
Barris and Luckman get into a stupid fight with a hammer and a rock as if they were drunk, Arctor hallucinates as if he was on shrooms/LCD/some type of hallucinate, Barris can appear very intense as if he's on cocaine/ecstasy or any other amphetamine, Arctor and Donna appear very relaxed and mellow as if they're stoned or on a downer, awesome stuff.
And no, I haven't done any drugs besides weed and alcohol but I've been around people who are high on harder drugs and I could see the similarities in this movie.
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