I've always thought that, whether it was just Jez or both Jez and Mark who knew her before she came into the show, she was called that because the social circle that they were in included two women called Susan (or variation of). As she was the tallest of the two, they called her 'Big Suze'.
I also reckon that when they cast the role, because her name was mentioned in the first series before she finally appeared in the first episode of the third series, they opted for someone who was on the tall side, possibly indicating as to why she got her nickname.
Big Suze is lovely and gorgeous... I can see why Jez (and Mark in 'Sistering') fancies her!
Hanging on in quiet desperation is the English way
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