Have to respectfully disagree with Vic being the main reason. Shane said as much in his suicide note, they all made each other worse, one really wasn't better than the other. Their greed was their downfall. Not Lem burning the money, not Lem taking the heroin to cover Shane, or even Shane getting in bed with Antwon. That was all apart of the domino effect that stemmed from ripping off the money train.
Gilroy foreshadowed it as well in "Coyotes." When he gets tossed in the van and Vic tells him Shane will kill him if he crosses the boarder again, Gilroy says somethinh along the line of "Don't get too greedy Vic, i did, there's a lesson there."
On a side note, i never realized how brilliantly titled the second season finale, "Dominoes Falling," really is until now in hindsight.
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