(Possible spoilers) Shinichi/Jimmy and alchohol
You know how he can temporarily revert back to normal with the use of some sort of Chinese alchohol and the capsule that Ai/(I don't remember the American name)is developing? Well, if alchohol kill hundreds of braincells each time he does that, d'you think he'd have to give up his detective career by the time he permenantly remains Kudo due to his increasing-lack of live braincells? If so...that sucks for him!!! (not to mention the other side effects of drinking loads of alchohol if Conan takes forever to get back to normal permenantly)
-----------
"I'm assuming that's a joke. I'm ignoring you for time reasons." -Wilbur Robinson