It has about the same continuity with the Caan/Patinkin film, as HIGHLANDER: THE SERIES had with the Christopher Lambert film. Which is, to say, not a heck of a lot. You would be better off imagining the original ALIEN NATION and its TV spin-off as occurring on separate-yet-parallel Earths.
On Earth-1, the mind-controlling substance was an addictive liquid drug called "ja'bro'ka." On Earth-2, it was an invisible gas. On Earth-1, too much of the drug resulted in the user mutagenically "Hulking out." On Earth-2, that aspect was explained away (in the series premier) as a Scooby Doo-like hoax being perpetrated by some blue-collar Purists who used to do special effects for movies.
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