The doors are chiefly to protect people from the blast but even though radioactive fall-out is not toxic for weeks on end, Jim and Hilda accelerated things a bit by "forgetting" they were to remain in the inner core or refuge. They must have inhaled a heck of a lot of that stuff and quickly developed all the symptoms of radiation poisoning (hair loss, vomitting, headaches, lesions etc).
I still suspect that the dust would of course infiltrate the shelter so short of a specialist suit I doubt they would have survived.
Lest we forget, the water supply was cut off also so they would eventually have died of thirst and the water would also have been contaminated.
I often drink to make people seem more interesting
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