Saddest episodes?
"I Love You, Brandon"
"Cherie Lifesaver"
"Changes"
"Accidents Happen"
"The Anniversary"
I felt that "Changes" was very depressing and quite realistic. The scene when Punky cuddles next to Henry while he was sleeping in the hospital is so sad. Even though throughout the episode was was humor, the tone of the episodes was still very depressing.
The episodes "I Love You, Brandon" and "The Anniversary" really got to me, the climaxes to those episodes are so heartwrenching...especially Cherie's performance in cemetery scene was powerful and realistic.
The scene in "Cherie Lifesaver" that I felt was sad was when Alan started crying because he felt guilty that he couldn't help Cherie.
Even though this show was cutesy, innocent and a bit corny most of the time, the special episodes really packed an emotional punch.