C'mon, Why Not a Female Host for Christsakes?!
Might sound stupid, but it would seem to me that doing something really DIFFERENT like that would boost ratings.
My picks (not sure if any would ever wanna do it) would be:
-Rosie O'Donnell
-Kathy Griffin
-Whoopi Goldberg
-Joy Behar
-That chick on Glee (don't remember her name, but she also plays the psychiatrist on Two and a Half Men).
Who else?