Guest stars

If you're asking about "up and coming" actors, one had Harrison Ford and one had Robert Urich. The last episodes had Leslie Nielson (who was already well-known, of course, but this was before all those comedies of his). The last ones also had Carl Weathers and A. Martinez.

In "73 you got Tom Nardini as a Native American avoiding having his image stolen by a camera & eventually stick fighting with ol' "Grasshoper" over a very shallow ravine! Never before has Italy been so misrepresented on film!

William Shatner chews the scenery marvelously as Brandywine Gage, with Frances Nuyen (you'll recognize the face if not the name) as his wife.

Barbara Hershey shows up in one flashback episode -- actually a two-parter I think -- as Caine's tragic love interest. But she was known as Barbara Seagull back then. She's good, though she does not look remotely Asian.

Gary Busey is in an episode. So are Richard Hatch, Tim Matheson, Roger E. Mosley, Anthony Zerbe, Tina Louise (Ginger from Gilligan's Island), Sondra Locke, and the great Andrew Robinson. Ken Swofford shows up a couple different times. Wilford Brimley is in one. One two-part episode has Patricia Neal, Eddie Albert, and his son Edward Albert, and is a high-point in the series. As another person mentioned, the four-part episode that wraps up the series (though three more episodes were shown afterwards) has Leslie Nielson (playing quite a villain), Carl Weathers, A Martinez and John Vernon (Dean Wormer from Animal House).

It's also fun to see the whole Carradine clan involved. John Carradine (David's father, and a great actor from the classic Hollywood era) appeared in three episodes as the same character, Serenity Johnson. Robert Carradine plays the mute Sonny Jim in one episode and is mentioned in another. Keith Carradine plays the teenage Caine in all the flashback sequences.

Of course, Hollywood didn't have many Asian actors, so the show cast just about every one you can think of, and often brought them back several times in different roles. Clyde Kusatsu (another guy about whom you'd say "Oh, him!" if you saw him) shows up a bunch of times in different roles.