One (inevitable) plot hole?
If Reed knows from long, sad experience that he becomes a wolf-man every full moon, why doesn't he take precautions accordingly? His most ravenous scene, when his transformation begins with a sweating fever in the crowded tavern and ends tragically with the loss of at least two characters, is "logically" speaking, out of place. If Leon has learned anything, it's that he is not safe on full moon nights - and neither is anyone else (unless they love him unreservedly). He just should have stayed away from the tavern that night. But had he done so, then of course we probably would have had a much more truncated and even unengaging film...
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