Stewart was evidently very interested in getting the role, but Hitchcock instinctively felt it wasn't a good fit.
Hitchcock would evidently at some point "blame" Stewart's aging appearance for the box office middling results of Vertigo(I somewhat agree, but it was the story that turned mass audiences off.) And in "Bell Book and Candle" of 1958, Stewart seemed too old for what was essentially a Cary Grant part, anyway(even if Grant was OLDER than Stewart.)
Personally, I think that James Stewart would have spoiled the crop duster scene because whereas Cary Grant in a suit looked oddly out of place on the open prairie...Western Star James Stewart would have looked just fine there.
Had Grant said "no" to North by Northwest(and he tried to get out of it), I could see Roger Thornhill more effectively played by William Holden or Rock Hudson before I would have gone to Stewart.
Funny: in the film "Dallas Buyers Club," the Matthew McConaghey character, in noting Rock Hudson's death from AIDS, has this exchange with another man:
Other man: Who's Rock Hudson?
MM: A movie star. Haven't you seen North by Northwest?
So...there's my case made for me.
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