Plot holes
I love this movie. Just wanted to make that clear. But there are plot holes.
First off, when did Grandi ever get the chance to contact his nephews and tell them Mrs. Vargas was at the American motel, and that they should go there and set things up to make her look like a drooling dope fiend? Grandi was picked up by Menzies when Susan was dropped at the motel, and then driven all the way to Sanchez's apartment. By the time Menzies and Grandi arrive at Sanchez's, the nephews are already at the American motel, preparing to make their move on Susan.
Secondly, after Mike Vargas goes to the American motel and discovers his wife missing, he travels back to Los Robles, drives right past the building where his disoriented wife is standing on the balcony screaming, and proceeds to Grandi's bar. He storms inside, and a huge fight breaks out. Seconds later, the police arrive, break up the fight, and Vargas is informed his wife was just picked up by the vice squad and arrested for, among other things, murder. How could all of that happened in that short span of time? Also, he is informed his wife was found on a bed in the building with drugs. How could she have been found on a bed when she was on the balcony?