Actually, a far bigger plot hole is that in exchanging heads with a fly, the scientist would have traded a brain with about 86 billion neurons, for one with only about 135,000. The scientist's head was gone, replaced with a fly head, equipped with a fly brain. He would not have been capable of any of the things we see him do in the movie, like trying to conceal from his wife what had happened to him, burning his notes, and killing himself in despair when he realizes there's no hope of reversing what's happened to him. Even assuming the clumsily produced hybrid organism could have survived for more than a few seconds (unlikely), he simply wouldn't have had the human-level intelligence he continued to display after the incident.
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April-151-CT (10210)
3 years ago
I would try to reason that inconsistency with how inconsistent the actual DNA exchange was to begin with. A fly hand and a fly head. No fly leg or foot etc. So then it would be ok to assume that the brain of each of them didn't fully exchange. Maybe they both had a partial brain exchange. That's why Andre-fly had a hard time doing some things but was able to do other things and that's why Fly-Andre was able to speak. They both had parts of their own brains and parts of the other's brain all mixed together. And eventually their DNA probably would've fully taken over each other had they'd been around long enough for it to have happened. Just a way to justify the inconsistencies.
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