One of the things that makes this film so good
Is that there are two superior actors in major roles; Patricia Neal and Sam Jaffe which is rare in sci-fi, not to mention a good director in Robert Wise. The only other sci-fi film that i can think of with 2 top actors is Them with Edmond Gwen and James Whitmore. Maybe Spencer Tracy and Ingrid Bergman in Dr. Jekyll and Mr. Hyde (1941) but i don't call that a strict sci-fi, there's other things like psychology and social norms involved.
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