Please cast him in a comic-book film
John Lithgow is one of my all-time favourite actors at playing villains. His mocking, supercilious voice is perfect for a baddie, as he proved in Cliffhanger, Ricochet, Santa Claus: The Movie and as the voice of Lord Farquaad in 'Shreck'.
He'd be perfect as a Marvel or DC villain, preferably either The Vulture (Marvel) or The Scarecrow (DC).