For those who travel a question?

Is there a fail safe way to safeguard your luggage for flight against potential drug smugglers, looking to turn you into their drug mule? Of course we've probably heard about rechecking your bags just before arriving at the airport and so on. But there's so many sneaky tactics these scoundrels can utilize I'm sure, like possibly placing a package in a suitcase while in transit from the hotel shuttle to you, or even somehow doing it while you move it to the bag check in. Is it possible and advisable to willfully ask for your bag to be searched just prior to check in by someone else in the presence of airport staff? Or could that be no better than being caught by security somehow if it was there and volunteering your neck for a noose regardless of your innocence in this case? Because in some countries, they've been known to execute those caught and convicted of drug trafficking.