Thrillers which take place in motels??

The Motel Life (2012)

The Bag Man (2014) - Robert De Niro and John Cusack

The Nature of the Beast (1995)

No Vacancy (2012) - also known as The Helpers

Identity (2003) - John Cusack again

Psycho (1960) - and its sequels and remake

I already have enough weird friends as it is.

It's more a dark comedy/horror than a thriller, but I'd recommend Bug (2006)

"Psycho" (1960). It's a must see!!

CARPE DIEM

Included only a few titles more not yet mentioned, there's not too many more great or good motel thrillers, sadly. Although I did include a list of some Hotel thrillers in case any interest you. In order by release date. I hope it helps! ;)


MOTEL:
1980 Motel Hell (Rory Calhoun)
1986 Mountaintop Motel Massacre (Bill Thurman)
2007 The Hitchhiker (Jeff Denton)
2008 Vacancy 2: The First Cut (Agnes Bruckner)

HOTEL:
1945 And Then There Were None (Barry Fitzgerald)
1952 Don't Bother To Knock (Marilyn Monroe)
1960 The City of the Dead (Patricia Jessel)
1980 Funeral Home (Kay Hawtrey)
1980 The Shining (Jack Nicholson)
1981 Ghostkeeper (Riva Spier)
1987 Bloody New Year (Suzy Aitchison)
1989 Puppetmaster (William Hickey)
2001 The Business of Strangers (Stockard Channing)
2002 Dirty Pretty Things (Audrey Tautou)
2004 The Toolbox Murders (Angela Bettis)
2004 Hotel (Franziska Weisz)
2006 Dead in 3 Days (Sabrina Reiter)
2007 1408 (John Cusack)
2011 The Innkeepers (Sara Paxton)
2013 Horror Story (Karan Kundra)


"I'll send you a copy." BAM! Bitch went down. "I'll send you a copy." BAM! Syd! Superbitch! - Scream

Although by no means exclusively, a good deal of the action takes place in motels in No Country For Old Men (2007)
Identity (2003)
When Strangers Appear (2001)


"Barney Sloane...That's my new name...My old one's a little more Italian."

- The Wrong Man (1993)
- Reeker (2005)

You may find more here:
- http://www.imdb.com/search/keyword?keywords=motel&genres=Thriller


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2 of Steve McQueen's films:

The Getaway

Bullit

Touch of Evil has Janet Leigh menaced in a motel, an apparent influence on Psycho. I suppose it could be called a crime thriller.