When I got the hang of the game, I mostly stuck to the default Handgun (stats, too), used the village's shotgun until I got the striker, and replaced the bolt-action rifle as soon as the semi-auto was available (basic scope until infrared).
But you could get through the game just fine without the semi-auto if you kept a lot of grenades when you got to the island (what was it, 4 or 5 explosions per regenerator?), but I'm a guy who kills every enemy if there's a cap.
The Mine Thrower made the stage with the fire-breathing dragon statues a breeze. You could just snipe the masked Los Illuminados lying in wait before they knew you were there. And from the entrance.
It's a pretty good gun if you make space for it. I usually keep three full-heals, one slot of handgun ammo, two for TMP, and horde everything else.
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