I'd say Nate, simply because he never gets the treasure, and only at the end of four games does he get the girl.
I'd also say that Agent 47 is as well, in so far that every assignment seems to affect him in some way, most noticeable in 2 and Contracts!
Big Boss, had a hard life...
Conker.
Can't even get a new game.
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Listen to Iced Earth and play Doom
Big boss:
MGS3: loses his mentor, loses his chinese spy girl/boobs
peace walker: gets duped by another blonde girl who doesn't even have boobs.
Ground zeroes, loses everything he built in peace walker and falls into a deep coma for a decade.
Phantom pain: loses his ability to be the main character, and talk, gets to backseat while some nobody becomes a better soldier than he, a cuck in his own videogame where Huey should be the only cuck present.
metal gear: spends time backseating to his doppelganger some more
Metal gear 2: watches as his son kills him amd puts him in another coma (another?)
for a long time, loses another legacy. Wakes up in time for MGS4's ending where he dies of foxdie but not before delivering a slightly more interesting monologue than any other character in thegame had delivered at that point.
Also his sons grew up hating him, as did his brother in arms Kaz Miller. gets to watch as his son is trained by his newly made enemy.
Max Payne
I...drink...your...MILKSHAKE!
I DRINK IT UP!!!
Actually this is probably the best bet.
The best browser game since browsers could game #browserrights -> www.TankWars.io
You just posted some massive spoilers to anyone who hasn't played all Uncharted games...
I always tell the truth, even when I lie.